Like many other conditions, family history plays a role in risk for Alzheimer's. Specifically, Alzheimer's disease risk increases if close family members have the condition. And, thanks to decades of research, we know more about this condition than ever before—including just what heritable traits put someone at risk.
Many of the symptoms of this condition are caused by amyloid plaque buildup and tau tangles (types of proteins) in the brain. According to recent research, different heritable high-risk genes and rare genetic variants (mutations) of them could make someone more likely to develop these hallmark plaques and tangles in the brain, including:
While these genes might sound scary at first, it's important to note that presence of these genes/genetic variants does not necessarily mean that someone will develop dementia.